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#1 04-06-2019 10:02:23

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The so-called "trispecific" antibody, made by researchers from the U.S. National Institutes of Health (NIH) and the Paris-based pharmaceutical company Sanofi Erik Haula Finland Jersey , works by binding to three different critical sites on HIV.


After exposing 24 monkeys to two strains of a monkey form of HIV, researchers found the majority of those receiving either PGDM1400 or VRC01 developed infection but all those receiving the triple combination were fully protected from the virus.


The three-pronged antibody was also found able to stop a greater number of HIV strains from infecting cells in the laboratory more potently than natural, single antibodies.


"Plans are under way to conduct early-phase clinical trials of the 'trispecific' antibody in healthy people and in people living with HIV in the hope that it could eventually be used for long-acting HIV prevention and treatment," the NIH said in a statement.


"By binding to three different sites on the virus, the new antibody should be harder for HIV to dodge than natural Mikael Granlund Finland Jersey , single antibodies."


In another study published in the journal Science Translational Medicine, researchers administered two different bNAbs to monkeys before infecting them with two strains of a monkey form of HIV.


Monkeys receiving either of the two antibodies individually all became infected, yet those with both antibodies conferred 100 percent protection.


"These data reveal that single bNAbs efficiently select resistant viruses from a diverse challenge swarm to establish infection, demonstrating the importance of bNAb cocktails for (HIV) prevention," said the study led by researchers from the Harvard University.


SOFIA Valtteri Filppula Finland Jersey , March 27 (Xinhua) -- Bulgaria's triple jumper Gabriela Petrova tested positive for meldonium that has been headlined recently.


The 23-year-old European indoor triple jump silver medalist had taken the substance in 2015 while it was not yet listed as a banned substance by World Anti-Doping Agency (WADA), said her manager Venitsa Atanasova on Sunday.


The test was conducted in Bulgaria on February 6, she added.


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